Formal Concept Analysis and Knowledge Integration for Highlighting Statistically Enriched Functions from Microarrays Data
نویسنده
چکیده
In this paper we introduce a new method for extracting enriched biological functions from transcriptomic databases using an integrative bi-classification approach. The initial gene datasets are firstly represented as a formal context (objects × attributes), where objects are genes, and attributes are their expression profiles and complementary informations of different knowledge bases. After that, Formal Concept Analysis (FCA) is applied for extracting formal concepts regrouping genes having similar transcriptomic profiles and functional behaviors. An enrichment analysis is then performed in order to identify the pertinent formal concepts from the generated Galois lattice, and to extract biological functions that could participate in the proliferation of cancers.
منابع مشابه
Formal Concept Analysis for Knowledge Discovery from Biological Data
Due to rapid advancement in high-throughput techniques, such as microarrays and next generation sequencing technologies, biological data are increasing exponentially. The current challenge in computational biology and bioinformatics research is how to analyze these huge raw biological data to extract biologically meaningful knowledge. This chapter presents the applications of formal concept ana...
متن کاملElasto-plastic analysis of discontinuous medium using linearly conforming radial point interpolation method
In this paper, the linearly conforming enriched radial basis point interpolation method is implemented for the elasto-plastic analysis of discontinuous medium. The linear conformability of the method is satisfied by the application of stabilized nodal integration and the enrichment of radial basis functions is achieved by the addition of linear polynomial terms. To implement the method for the ...
متن کاملFCART: A New FCA-based System for Data Analysis and Knowledge Discovery
We introduce a new software system called Formal Concept Analysis Research Toolbox (FCART). Our goal is to create a universal integrated environment for knowledge and data engineers. FCART is constructed upon an iterative data analysis methodology and provides a built-in set of research tools based on Formal Concept Analysis techniques for working with object-attribute data representations. The...
متن کاملUsing Formal Concept Analysis and Information Flow for Modelling and Sharing Common Semantics: Lessons Learnt and Emergent Issues
We have been witnessing an explosion of user involvement in knowledge creation, publication and access both from within and between organisations. This is partly due to the widespread adoption of Web technology. But, it also introduces new challenges for knowledge engineers, who have to find suitable ways for sharing and integrating all this knowledge in meaningful chunks. In this paper we are ...
متن کاملExtended Finite Element Method for Statics and Vibration Analyses on Cracked Bars and Beams
In this paper, the extended finite element method (XFEM) is employed to investigate the statics and vibration problems of cracked isotropic bars and beams. Three kinds of elements namely the standard, the blended and the enriched elements are utilized to discretize the structure and model cracks. Two techniques referred as the increase of the number of Gauss integration points and the rectangle...
متن کامل